The dosage is based on your medical condition, age, and response to treatment.If directed by your doctor, use this medication regularly in order to get the most benefit from it. Use Caution/Monitor. Webformulation. and transmitted securely. Monitor Closely (1)lorazepam increases and arformoterol decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Minor (1)lorazepam and eucalyptus both increase sedation. Profound sedation, respiratory depression, coma, and death may result if coadministered. pregabalin, lorazepam. These findings suggest that standardized benzodiazepine conversions successfully achieved consistent Withdrawal Assessment Tool-Version 1 scores compared with preconversion values. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and methylenedioxymethamphetamine decreases sedation. Modify Therapy/Monitor Closely. lorazepam and benperidol both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and hydromorphone both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. lorazepam, clobazam. Use Caution/Monitor. Seventy-one patient encounters were analyzed (median age, 2.5 yr; interquartile range, 1.25.3). Enhanced metabolism incr levels of hepatotoxic metabolites. Our benzo calculator uses the first mentioned and most popular option duration. Benzodiazepine conversion calculations were applied according to institutional clinical pathway guidance. restrictions. Effect of interaction is not clear, use caution. A cost analysis of enterally administered lorazepam in the pediatric intensive care unit. lorazepam and nortriptyline both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. Either increases toxicity of the other by pharmacodynamic synergism. %PDF-1.6 % 4 0 obj Use Caution/Monitor. Use Caution/Monitor. 0000005197 00000 n Modify Therapy/Monitor Closely. lorazepam and amoxapine both increase sedation. Either increases toxicity of the other by Other (see comment). Effect of interaction is not clear, use caution. PRECAUTIONS: Before taking lorazepam, tell your doctor or pharmacist if you are allergic to it; or to other benzodiazepines (such as alprazolam, clonazepam, diazepam); or if you have any other allergies. Access your plan list on any device mobile or desktop. H\TKoAqs;O Use Caution/Monitor. lorazepam increases and lisdexamfetamine decreases sedation. Monitor Closely (1)cyclizine and lorazepam both increase sedation. lorazepam and ziprasidone both increase sedation. Monitor Closely (1)lorazepam and carisoprodol both increase sedation. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. azelastine and lorazepam both increase sedation. We compare each one of our benzodiazepines to alprazolam. Use Caution/Monitor. Monitor Closely (1)gabapentin enacarbil, lorazepam. chlordiazepoxide and lorazepam both increase sedation. Minor/Significance Unknown. Individual plans may vary WebNo lag times were observed after intramuscular injection of lorazepam; absorption was first order, with t 1/2a values averaging 12 (2-mg dose) and 19 (4-mg dose) min. HHS Vulnerability Disclosure, Help A1 - Kim,Paul,M.D., Ph.D. lorazepam and ganaxolone both increase sedation. Modify Therapy/Monitor Closely. sufentanil SL, lorazepam. Use Caution/Monitor. Applies only to oral form of both agents. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. Why are benzodiazepines so popular? lorazepam and topiramate both increase sedation. 0000008826 00000 n Monitor Closely (1)lorazepam and levorphanol both increase sedation. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. WebAntipsychotics for initial management of the acutely agitated adult patient with psychosis. Monitor Closely (1)lorazepam and perphenazine both increase sedation. LV>T6If7>LYJTgJ^kyf>[7Sz]>mCh^3r3a2Lmm$9_5y/;D|s }3a7+NGv46p?MISiZ?dV?pmSosEIN.6DLY}%OL!+Cuf^C;\EvwgOv|2> V,>1w|>>O[[ej,UdSg,ufiEI'&c3Y_$x_'Ifm9s;KY|{AuLTiv[V>n~>r`-@Z(^++Gj~Stsz|6jmm/1dEIz$+ZE7c0rw@GRt=%K2*#g`9'Jp?Hol+c/1K6//1-=d#~t*8t)~H0E>ue)'U'$L Let's practice it all with a small example: Take a closer look our equivalent benzodiazepine calculator gives you both generic (pharmaceutical) and brand names of all the drugs! Serious - Use Alternative (1)hydrocodone, lorazepam. Use Caution/Monitor. Coadministration may potentiate the CNS-depressant effects of each drug. ER -, Your free 1 year of online access expired. lorazepam and quazepam both increase sedation. Monitor Closely (1)teduglutide increases levels of lorazepam by Other (see comment). Patients treated with selinexor may experience neurological toxicities. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. lorazepam and lofepramine both increase sedation. 290.914.916.010. Monitor Closely (1)lorazepam and desipramine both increase sedation. x]r}g*~qXE-GmqyHJbBr^|c],^ @r\4Plxy+XNr^X/ estazolam and lorazepam both increase sedation. Minor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. Use Caution/Monitor. Greenblatt DJ, Wright CE. Monitor Closely (1)butabarbital and lorazepam both increase sedation. lorazepam and amitriptyline both increase sedation. Then type a starting value in the top FROM input box. Manage and view all your plans together even plans in different states. amobarbital and lorazepam both increase sedation. Use Caution/Monitor. lorazepam increases and dexfenfluramine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. Caffeine component of green tea may decrease sedative effects of benzodiazepines. Use Caution/Monitor. \x}qV^5gycZz}.G 1-qswCak 2%GwmA9Ya IF}-)w%*LzRX=6s-nN 7o(4 "OYKv>3tYjAOrNz#% ?W-. Effect of interaction is not clear, use caution. selinexor, lorazepam. Effect of interaction is not clear, use caution. Properly discard this product when it is expired or no longer needed. Monitor Closely (1)lorazepam and doxepin both increase sedation. Use Caution/Monitor. Intravenous to Oral Conversion for Antimicrobials 1-20-6-1-010 Author(s): Antimicrobial Stewardship Program Coordinator Page 6 of 6 Issuing Authority: Vice President Medicine and Clinical Programs; Regional Director, Pharmacy Services Use Caution/Monitor. Monitor Closely (1)lorazepam and daridorexant both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Biotin supplementation may be necessary. Monitor Closely (1)oliceridine, lorazepam. Benzodiazepines are a group of drugs used for treating anxiety they will also make you feel more relaxed, help you fall asleep faster and on top of that they may combat a few kinds of seizures. Monitor closely for signs of respiratory depression and sedation. =BQPe+ $5-Xte~aPaqwCJvOXP.d<0 ?G@Pw1$ O\6a+_~}{GP2,#:+ Use Caution/Monitor. Monitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. Use Caution/Monitor. Greenblatt DJ, Shader RI, MacLeod SM, et al. Use Caution/Monitor. Use Caution/Monitor. clonidine, lorazepam. WebLorazepam (PO/IV): 0.025 - 0.1 mg/kg/dose (Max: 2 mg) Q4-6 Midazolam (PO) 0.25 - 0.5 mg/kg/dose (Max: 20 mg) PRN Voriconazole (IV/PO) 2 - 12 yo: 9 mg/kg/dose x 2 doses then 8 -9 mg/kg/dose Q12 12 yo: 6 mg/kg/dose x 2 doses then 3 - Use Caution/Monitor. Effect of interaction is not clear, use caution. If you log out, you will be required to enter your username and password the next time you visit. Use Caution/Monitor. Effect of interaction is not clear, use caution. WebPharmacist initiated IV to PO conversion program of antimicrobials. Modify Therapy/Monitor Closely. Use Caution/Monitor. lasmiditan, lorazepam. Either increases toxicity of the other by pharmacodynamic synergism. 0000008055 00000 n Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and propylhexedrine decreases sedation. Minor/Significance Unknown. Use Caution/Monitor. lorazepam increases and fenfluramine decreases sedation. hydroxyzine and lorazepam both increase sedation. If you take it once daily at bedtime and miss a dose, do not take it the following morning. 0000003779 00000 n There have been postmarketing reports of coma and death with coadministration of buprenorphine and benzodiazepines. etomidate and lorazepam both increase sedation. Monitor Closely (1)lemborexant, lorazepam. Use Caution/Monitor. IV to PO Conversion Possible If: (ALL Criteria Should be met to Effect of interaction is not clear, use caution. lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Careers. The .gov means its official. your express consent. lorazepam and zotepine both increase sedation. The above information is provided for general Minor (1)gemifloxacin increases levels of lorazepam by decreasing metabolism. Monitor Closely (1)lurasidone, lorazepam. Use Caution/Monitor.Minor (1)dexmethylphenidate increases effects of lorazepam by decreasing metabolism. Use Caution/Monitor. EPS risk. 0000063185 00000 n lorazepam and ethanol both increase sedation. Use Caution/Monitor. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Well, the benzodiazepine conversion calculator has got your back! [7Yy ]6IF  Canada residents can call a provincial poison control center. zolpidem, lorazepam. HOW TO USE: See also Warning section.Read the Medication Guide provided by your pharmacist before you start taking lorazepam and each time you get a refill. Minor/Significance Unknown. lorazepam and dantrolene both increase sedation. Modify Therapy/Monitor Closely. endobj Patient demographics, benzodiazepine dose escalations, as needed benzodiazepine requirements, and severe adverse events within 48 hours of conversion were assessed. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (2)lorazepam, loxapine. Use Caution/Monitor. Use Caution/Monitor. Effect of interaction is not clear, use caution. Davidson JR. Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Use Caution/Monitor. WebBenzodiazepine Dose and Route Equivalence Diazepam 10mg PO/PR 2.5mg subcut midazolam Clonazepam 1mg PO/SC Lorazepam 1mg PO/IV Oxazepam 15 to 30mg PO Temazepam 10mg PO Midazolam Nasal Spray 5 sprays (=2.5mg) Example: A patient has been taking 1 mg lorazepam PO (equivalent to 2.5 mg subcut midazolam) + used Use Caution/Monitor. Monitor Closely (1)lorazepam and papaveretum both increase sedation. Applies only to oral form of both agents. Minor/Significance Unknown. Lorazepam belongs to a class of drugs known as benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. Use Caution/Monitor. Use lowest dose possible and monitor for respiratory depression and sedation. lorazepam decreases effects of rocuronium by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Limit dosages and durations to the minimum required. Possible risk of cardiorespiratory collapse. Minor/Significance Unknown. The sleep calculator can help you determine when you should go to bed to wake up happy and refreshed. Severe adverse events associated with oversedation and/or withdrawal were minimal and confounded by underlying disease states. % Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Paradoxical reactions (anxiety, excitation, agitation, hostility, aggression, rage), Use of injectable dosage form in premature infants (contains benzyl alcohol), Concomitant use of benzodiazepines, including lorazepam, and opioids may result in profound sedation, respiratory depression, coma, and death (see BBW), Advise both patients and caregivers about the risks of respiratory depression and sedation when lorazepam is used with opioids; advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined, Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS depressants, may lead to potentially fatal respiratory depression, Not recommended for use in patients with primary depressive disorder or psychosis, Injection contains benzyl alcohol associated with potentially fatal "gasping syndrome" in neonates and an increased incidence of kernicterus, particularly in small preterm infants; if patient requires more than recommended dosages or other medications containing this preservative, practitioner must consider daily metabolic load of benzyl alcohol from combined sources, Prolonged use may lead to physical and psychological dependence especially in patients with history of alcohol or drug abuse; risk of dependence is decreased with short-term treatment (eg, 2-4 weeks); evaluate need for continued treatment prior to extending therapy duration, Use of drug, particularly in patients at elevated risk, necessitates counseling about risks and proper use of drug along with monitoring for signs and symptoms of abuse, misuse, and addiction; do not exceed recommended dosing frequency, Avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (eg, opioid analgesics, stimulants); advise patients on proper disposal of unused drug; if a substance use disorder is suspected, evaluate patient and institute (or refer them for) early treatment, as appropriate, For patients using treated more frequently than recommended, to reduce risk of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific plan should be used to taper the dose), Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use, In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months, Use caution in patients with history of suicide attempt or drug abuse, Do not withdraw abruptly after prolonged use; terminate dosage gradually, Use caution in patients with impaired gag reflex, May cause CNS depression, impairing physical and mental abilities; caution patients to not operate dangerous machinery or motor vehicles, Use caution in patients with respiratory disease, including COPD or sleep apnea, Hyperactive or aggressive behavior and other paradoxical reactions reported with use, Caution patients that tolerance for alcohol and other CNS depressants will be diminished, There is a pregnancy registry that monitors pregnancy outcomes in woman exposed to psychiatric medications; healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Psychiatric Medications at 1-866-961-2388 or visiting online at https://womensmentalhealth.org/pregnancyregistry/Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and/or neonatal withdrawal; available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects, Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia, and sedation in neonates; monitor neonates exposed to this medication during pregnancy or labor for signs of sedation, respiratory depression, hypotonia, and feeding problems, Monitor neonates exposed to therapy during pregnancy for signs of withdrawal; manage these neonates accordingly, Advise pregnant females who are administered this medication late in pregnancy that therapy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns; instruct patients to inform their healthcare provider if they are pregnant, There are insufficient data regarding obstetrical safety of parenteral lorazepam, including use in cesarean section; such use, therefore, is not recommended, This drug is present in breast milk; there are reports of sedation. Use Caution/Monitor. lorazepam and triazolam both increase sedation. Ask your pharmacist about using those products safely. Consider reducing the dose when concomitantly using UGT2B7 substrates. Consider decreasing the dose of these drugs when given coadministered with methylphenidate. Use Caution/Monitor. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Minor (1)lorazepam decreases levels of acetaminophen by increasing metabolism. C. The pharmacist must enter Epic order comments stating IV to PO Conversion per P&T policy for all interchanged orders. Comment: Drug combination has been found to be incompatible. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam and clomipramine both increase sedation. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. WebDiscuss IV methylpred. oliceridine, lorazepam. Use Caution/Monitor. Use Caution/Monitor. lorazepam increases and pirbuterol decreases sedation. Overdose is less probable; and, most of all. . Use Caution/Monitor. Monitor Closely (1)lorazepam and shepherd's purse both increase sedation. poor feeding and poor weight gain in infants exposed to benzodiazepines through breast milk; effects of this drug on milk production are unknown; developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for therapy and any potential adverse effects on breastfed infant from therapy or from the underlying maternal condition, Instruct patients to notify their healthcare provider if they are breastfeeding or intend to breastfeed; instruct breastfeeding patients who are administered this therapy to monitor infants for excessive sedation, poor feeding and poor weight gain, and to seek medical attention if they notice these signs. h>1rFv!J ` ,J P^ v V "stX^4(PFpT@D (h.=_)h29N= remimazolam, lorazepam. Monitor Closely (1)desflurane and lorazepam both increase sedation. Please try again soon. Use Caution/Monitor. 3 0 obj Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)lorazepam and trimipramine both increase sedation. Use Caution/Monitor. lorazepam decreases effects of cisatracurium by pharmacodynamic antagonism. Monitor Closely (1)cinnarizine and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Johns Hopkins Guide App for iOS, iPhone, iPad, and Android included. <>/Metadata 485 0 R/ViewerPreferences 486 0 R>> f[ey If you're taking any other medication than alprazolam right now, divide your dose by the number present by your drug's name, and then multiply it by the number written by the name of the drug you'd like to switch to (take a look at the example at the bottom of the page ). Should go to bed to wake up happy and refreshed encounters were analyzed ( age. 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